J. L. Castro-Mejia

Overcoming donor variability and risks associated with fecal microbiota transplants through bacteriophage-mediated treatments

This study develops modified fecal virome transplants (FVT) to reduce donor variability and infection risks in treating C. difficile infections, showing improved efficacy and safety in a mouse model.

Transfer of modified fecal viromes improve blood glucose regulation and alleviates symptoms of metabolic dysfunction-associated fatty liver disease in an obesity male mouse model

Modified fecal virome transplantation improves blood glucose regulation in obese mice without reducing weight gain, while unmodified FVT reduces immune cell proportions in adipose tissue.

The influence of early life exposures on the infant gut virome

This study investigates how early life factors influence the gut virome composition in infants, identifying environmental exposures that shape viral communities and their potential metabolic impacts.

Fecal virome transfer improves proliferation of commensal gut Akkermansia muciniphila and unexpectedly enhances the fertility rate in laboratory mice

This study shows that fecal virome transplantation increases Akkermansia muciniphila abundance in mice and unexpectedly raises fertility rates in co-housed pairs.

Faecal virome transplantation decrease symptoms of type-2-diabetes and obesity in a murine model

This study shows that faecal virome transplantation from lean donors reduces weight gain and improves glucose tolerance in obese mice, suggesting a role for gut viruses in metabolic health.

Physical fitness in community dwelling older adults is linked to dietary intake, gut microbiota and metabolomic signatures

The paper links physical fitness in older adults to dietary intake, gut microbiota, and metabolomic signatures, identifying key factors explaining individual variation in fitness.

Characterization of the vaginal DNA virome in health and dysbiosis: an opening study in patients with non-female factor infertility

This study characterizes the vaginal DNA virome in patients with non-female factor infertility and finds associations between viral community composition and bacterial dysbiosis.

Mouse vendor influence on the bacterial and viral gut composition exceeds the effect of diet

This study shows that differences between mouse vendors have a greater impact on gut bacterial and viral communities than diet.