NOD2 and TLR2 Signal via TBK1 and PI31 to Direct Cross-presentation and CD8 T Cell Responses
D. Corridoni, S. Shiraishi, T. Chapman, T. Steevels, D. Muraro, M.-L. Thezenas, G. Prota, J.-L. Chen, U. Gileadi, N. Ternette, V. Cerundolo, A. Simmons
This study identifies TBK1 and PI31 as key mediators of NOD2 and TLR2 signaling in dendritic cells, enhancing cross-presentation and CD8+ T cell responses against bacterial pathogens.
bioRxiv · Mar 8, 2019Immunology