Author

J.-L. Chen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1 Bioengineering· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Research Focus:benchmarking· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

U. Gileadi· 2 shared V. Cerundolo· 2 shared A. Bruening· 1 shared A. E. Powell· 1 shared A. Hartwig· 1 shared A. Simmons· 1 shared A. Townsend· 1 shared A. V. Hadjinicolaou· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersImmunology

U. Gileadi

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A stabilized MERS-CoV spike ferritin nanoparticle vaccine elicits robust and protective neutralizing antibody responses

A. E. Powell, H. Caruso, S. Park, J.-L. Chen, J. O'Rear, B. J. Ferrer, D. M. Belnap, A. Walker, A. Bruening, A. Hartwig, V. Ahyong, C. S. Dougherty, R. A. Bowen, J. E. Ledgerwood, M. S. Kay, , B. A. Palanski

This paper develops a stabilized MERS-CoV spike ferritin nanoparticle vaccine that elicits strong neutralizing antibodies in mice and non-human primates, providing protection against MERS-CoV infection.

bioRxiv · Jul 1, 2024Biochemistry

Self-Healable Spider Dragline Silk Materials

W.-C. Chen, R.-C. Wang, S.-K. Yu, J.-L. Chen, Y.-H. Kao, T.-Y. Wang, P.-Y. Chang, H.-S. Sheu, S. C. C. Chen, W.-R. Liu, T.-I. Yang, H.-C. Wu

This paper develops a self-healing spider silk material with tunable properties and demonstrates its application in wearable electronics.

bioRxiv · Apr 1, 2023Bioengineering

A dual mechanism of APC/C inhibition by MAP kinases

L. Sun, S. Bai, J.-l. Chen, D.-j. Deng, Z.-q. Luo, Y. Wang, Q. JIN

This study identifies two MAPK pathways that inhibit APC/C activity during mitotic arrest in fission yeast, clarifying their role in spindle checkpoint activation and chromosome segregation.

bioRxiv · Apr 1, 2022 · PreprintCell Biology

Semaphorin 3A induces cytoskeletal paralysis in tumor-specific CD8+ T cells

M. B. Barnkob, Y. S. Michaels, V. Andre, P. S. Macklin, U. Gileadi, S. Valvo, M. Rei, C. Kulicke, J.-L. Chen, V. Jain, V. Woodcock, H. Colin-York, A. V. Hadjinicolaou, Y. Kong, V. Mayya, , V. Cerundolo

This study shows Sema3A inhibits tumor-specific CD8+ T cell function by inducing cytoskeletal paralysis via NRP1 in the tumor microenvironment.

bioRxiv · Nov 20, 2019Immunology

NOD2 and TLR2 Signal via TBK1 and PI31 to Direct Cross-presentation and CD8 T Cell Responses

D. Corridoni, S. Shiraishi, T. Chapman, T. Steevels, D. Muraro, M.-L. Thezenas, G. Prota, J.-L. Chen, U. Gileadi, N. Ternette, V. Cerundolo, A. Simmons

This study identifies TBK1 and PI31 as key mediators of NOD2 and TLR2 signaling in dendritic cells, enhancing cross-presentation and CD8+ T cell responses against bacterial pathogens.

bioRxiv · Mar 8, 2019Immunology