Author

V. Cerundolo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 7 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:human· 8 Assay:proteomics· 6 Research Focus:cell type annotation· 5 Research Focus:host-pathogen & immune response· 5 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell signaling & trafficking· 3 Research Focus:differential expression· 2

Frequent Co-Authors

U. Gileadi· 4 shared C. Gonzalez-Lopez· 2 shared G. Prota· 2 shared J.-L. Chen· 2 shared M. Rei· 2 shared M. Salio· 2 shared P. Borrow· 2 shared P. Klenerman· 2 shared

Activity by Year

2017-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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4 shared papersImmunology

U. Gileadi

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

IFNgamma-dependent remodelling of the myeloid landscape underlies control of IFNgamma-insensitive tumours

V. W. C. Lau, G. Mead, J. M. Mazet, A. Krishnan, E. W. Roberts, G. Prota, U. Gileadi, V. Cerundolo, A. Gerard

The paper shows that IFN-gamma-insensitive tumours can still be controlled by immune responses, with IFN-gamma driving myeloid cell remodelling that enhances anti-tumour immunity.

bioRxiv · Mar 25, 2024Immunology

Immunofilaments Provide a Nanoscale Platform for In Vivo T Cell Expansion and Cancer Immunotherapy

L. Weiss, J. Weiden, Y. Dölen, E. Grad, E. A. W. van Dinther, M. Schluck, L. J. Eggermont, G. van Mierlo, U. Gileadi, A. Bartolo-Ibars, R. Raave, M. A. J. Gorris, K. Verrijp, M. Valente, B. Deplancke, , R. Hammink

This paper introduces immunofilaments that expand T cells in vivo, showing efficacy against melanoma when combined with immune checkpoint blockade.

bioRxiv · Oct 14, 2022Immunology

The P5-ATPase ATP13A1 modulates MR1-mediated antigen presentation

C. A. Kulicke, E. De Zan, Z. Hein, C. Gonzalez-Lopez, S. Ghanwat, N. Veerapen, G. Besra, P. Klenerman, J. C. Christianson, S. Springer, S. Nijman, V. Cerundolo, M. Salio

This study identifies ATP13A1 as a key regulator of MR1 surface expression through CRISPR/Cas9 knockout experiments in human cell lines.

bioRxiv · May 26, 2021 · PreprintImmunology

HLA-E restricted, HIV-1 suppressing, Gag specific CD8+ T cells offer universal vaccine opportunities

H. Yang, M. Rei, S. Brackenridge, E. Brenna, H. Sun, s. abdulhaqq, M. K. Liu, W. Ma, P. Kurupati, x. Xu, V. Cerundolo, E. Jenkins, S. J. Davis, J. B. Sacha, K. Frueh, , A. J. McMichael

The paper demonstrates that HLA-E restricted, HIV-1 specific CD8+ T cells can suppress HIV-1 replication in vitro, suggesting potential for a universal vaccine.

bioRxiv · Dec 1, 2020 · PreprintImmunology

Deep analysis of the USP18-dependent ISGylome and proteome unveils important roles for USP18 in tumour cell antigenicity and radiosensitivity

A. Pinto-Fernandez, M. Salio, T. Partridge, J. Chen, G. Vere, H. Greenwood, C. S. Olie, A. Damianou, H. C. Scott, H. J. Pegg, A. Chiarenza, L. Diaz-Saez, P. Smith, C. Gonzalez-Lopez, B. Patel, , B. M. Kessler

This study identifies novel ISGylation targets regulated by USP18, showing its role in enhancing tumour cell antigenicity and reducing radiosensitivity in CML cells.

bioRxiv · Mar 31, 2020 · PreprintCancer Biology

Semaphorin 3A induces cytoskeletal paralysis in tumor-specific CD8+ T cells

M. B. Barnkob, Y. S. Michaels, V. Andre, P. S. Macklin, U. Gileadi, S. Valvo, M. Rei, C. Kulicke, J.-L. Chen, V. Jain, V. Woodcock, H. Colin-York, A. V. Hadjinicolaou, Y. Kong, V. Mayya, , V. Cerundolo

This study shows Sema3A inhibits tumor-specific CD8+ T cell function by inducing cytoskeletal paralysis via NRP1 in the tumor microenvironment.

bioRxiv · Nov 20, 2019Immunology

The repertoire of serous ovarian cancer non-genetic heterogeneity revealed by single-cell sequencing of normal fallopian tube epithelial cells

Z. Hu, M. Artibani, A. Alsaadi, N. Wietek, M. Morotti, L. Santana Gonzalez, S. El-Sahhar, M. KaramiNejadRanjbar, G. Mallett, T. Shi, K. Masuda, Y. Zheng, K. Chong, S. Damato, S. Dhar, , A. A. Ahmed

The paper uses single-cell sequencing to identify non-genetic heterogeneity in serous ovarian cancer by analyzing normal fallopian tube epithelial cells and their subtype signatures.

bioRxiv · Jun 17, 2019Cancer Biology

NOD2 and TLR2 Signal via TBK1 and PI31 to Direct Cross-presentation and CD8 T Cell Responses

D. Corridoni, S. Shiraishi, T. Chapman, T. Steevels, D. Muraro, M.-L. Thezenas, G. Prota, J.-L. Chen, U. Gileadi, N. Ternette, V. Cerundolo, A. Simmons

This study identifies TBK1 and PI31 as key mediators of NOD2 and TLR2 signaling in dendritic cells, enhancing cross-presentation and CD8+ T cell responses against bacterial pathogens.

bioRxiv · Mar 8, 2019Immunology

Diverse Streptococcus pneumoniae strains drive a MAIT cell response through MR1-dependent and cytokine-driven pathways

A. Kurioka, B. van Wilgenburg, R. R. Javan, R. Hoyle, A. J. van Tonder, C. L. Harrold, T. Leng, L. J. Howson, D. Shepherd, V. Cerundolo, A. B. Brueggemann, P. Klenerman

This study shows that diverse Streptococcus pneumoniae strains activate MAIT cells via MR1-dependent and cytokine-driven pathways, with conserved riboflavin operon genes across strains.

bioRxiv · Jul 17, 2017Immunology