N. D. Grubaugh

Survey of white-footed mice in Connecticut, USA reveals low SARS-CoV-2 seroprevalence and infection with divergent betacoronaviruses

The study surveys white-footed mice in Connecticut, finding low SARS-CoV-2 seroprevalence and identifying two divergent betacoronaviruses.

Omicron-specific mRNA vaccination alone and as a heterologous booster against SARS-CoV-2

This study evaluates an Omicron-specific mRNA vaccine, showing it elicits strong antibody responses and outperforms WT boosters against Omicron and Delta variants.

Genomic and phenotypic analyses suggest moderate fitness differences among Zika virus lineages

The paper analyzes genomic and phenotypic data from Zika virus lineages to assess fitness differences during the 2015-2016 epidemic, finding moderate fitness changes but no significant virulence or transmission enhancement.

A stem-loop RNA RIG-I agonist confers prophylactic and therapeutic protection against acute and chronic SARS-CoV-2 infection in mice

This study shows that SLR14, a RIG-I agonist, prevents and treats SARS-CoV-2 infection in mice, including chronic cases and variants, through IFN-I responses.

Long SARS-CoV-2 nucleocapsid sequences in blood monocytes collected soon after hospital admission

The paper detects long SARS-CoV-2 nucleocapsid sequences in blood monocytes of patients within 2-6 days of hospital admission, suggesting early viral dissemination by myeloid cells.

Phylogeographic and phylodynamic approaches to epidemiological hypothesis testing

This study uses phylogeographic and phylodynamic methods to test hypotheses about West Nile virus dispersal and genetic diversity, finding temperature influences on spread and no strong evidence for migratory bird flyway restriction.

Exploratory neuroimmune profiling identifies CNS-specific alterations in COVID-19 patients with neurological involvement

The paper identifies CNS-specific immune alterations in COVID-19 patients with neurological symptoms, suggesting neuroinvasion and anti-neural autoimmunity as potential causes.

Two sides of a coin: a Zika virus mutation selected in pregnant rhesus macaques promotes fetal infection in mice but at a cost of reduced fitness in nonpregnant macaques and diminished transmissibility by vectors

This paper identifies a ZIKV mutation, M1404I, that enhances fetal infection in mice but reduces viral fitness and transmissibility in nonpregnant macaques and mosquitoes.

An amplicon-based sequencing framework for accurately measuring intrahost virus diversity using PrimalSeq and iVar

The paper evaluates PrimalSeq for measuring intrahost virus diversity, showing how factors like sequencing coverage and primer mismatches affect accuracy.

Adventitious viruses persistently infect three commonly used mosquito cell lines

The paper identifies persistent viral infections in four commonly used mosquito cell lines, showing that they harbor active viral replication and integration.

Common Piezo1 allele in African populations causes xerocytosis and attenuates Plasmodium infection

The paper identifies a common Piezo1 variant in African populations that causes xerocytosis and reduces Plasmodium infection.