Author

Tahra Kaur Luther

University of Michigan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:metabolism & bioenergetics· 1 Assay:proteomics· 1

Frequent Co-Authors

Afnan AlzamrooniiD· 3 shared Ahmed Abdel‐LatifiD· 3 shared Parisa ShabaniiD· 3 shared Anand Prakash SinghiD· 2 shared Rachel Lopez‐Schenk· 2 shared Rajesh Kumar ChaudharyiD· 2 shared Anand P. Singh· 1 shared Andrew Robbins· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersImmunology

Afnan AlzamrooniORCID

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3 papers

Recent·Most cited

Autotaxin Inhibition Ameliorates HFpEF Phenotype By Reducing LPA-Mediated Systemic Inflammation And Cardiac Remodeling

Rajesh Chaudhary, Andrew Robbins, Anand P. Singh, Parisa Shabani, Tahra Kaur Luther, Afnan Alzamrooni, Rachel Lopez, Tania Maheshwari, Nicolas Collins, Scott L. Hummel, Ahmed Abdel‐Latif

This study shows autotaxin inhibition reduces LPA-mediated inflammation and cardiac remodeling in HFpEF, improving diastolic function and fibrosis in mice and showing altered lysophospholipid profiles in humans.

bioRxiv · Aug 30, 2026 · PreprintImmunology

Soluble Urokinase Plasminogen Activator Receptor Primes Macrophages and Worsens Heart Failure with Preserved Ejection Fraction

Anand Prakash Singh, Parisa Shabani, Anis Ismail, Rajesh Kumar Chaudhary, Afnan Alzamrooni, Tahra Kaur Luther, Matthew Nho, Rachel Lopez‐Schenk, Chetna Soni, Sascha N. Goonewardena, Salim S. Hayek, Ahmed Abdel‐Latif

This paper shows that elevated suPAR worsens HFpEF by priming macrophages and amplifying inflammatory responses, identifying a therapeutic target for anti-suPAR antibodies.

bioRxiv · Jun 9, 2026 · PreprintImmunology

Targeting Metabolic Dysfunction and Inflammation with Sotagliflozin Reverses Diastolic Dysfunction in Experimental HFpEF

Parisa Shabani, Tahra Kaur Luther, Rajesh Kumar Chaudhary, Anand Prakash Singh, Afnan Alzamrooni, Olga G. Grushko, Nathan Levine, Rachel Lopez‐Schenk, Sascha N Goonwardena, Bertram Pitt, Ahmed Abdel‐Latif

This study shows that sotagliflozin improves diastolic dysfunction in HFpEF by enhancing lipid metabolism and reducing inflammation.

bioRxiv · Nov 27, 2025 · PreprintCell Biology