Afnan Alzamrooni

This study shows autotaxin inhibition reduces LPA-mediated inflammation and cardiac remodeling in HFpEF, improving diastolic function and fibrosis in mice and showing altered lysophospholipid profiles in humans.

This paper shows that elevated suPAR worsens HFpEF by priming macrophages and amplifying inflammatory responses, identifying a therapeutic target for anti-suPAR antibodies.

This study shows that sotagliflozin improves diastolic dysfunction in HFpEF by enhancing lipid metabolism and reducing inflammation.

This study examines how mouse strain and housing temperature affect metabolic syndrome and HFpEF development in a two-hit model, finding strain-specific responses to thermoneutral conditions.

This study identifies unique metabolic adaptations in Acomys cardiomyocytes that enhance cardiac recovery after myocardial infarction compared to Mus musculus.

The paper shows that the paraxial head mesoderm in chicken embryos retains cardiac competence until early head fold stages, after which Bmp signals drive a shift to head skeletal muscle programmes.