PACT prevents aberrant activation of PKR by endogenous dsRNA without sequestration
Sadeem Ahmad, Tao Zou, Jihee Hwang, Linlin Zhao, Xi Wang, Anton Davydenko, Ilana Buchumenski, Patrick Zhuang, Alyssa R. Fishbein, Diego Capcha-Rodriguez, Aaron Orgel, Erez Y. Levanon, Sua Myong, James Jeiwen Chou, Matthew M. Meyerson, Sun Hur
This study shows PACT inhibits PKR activation by endogenous dsRNA through restricting PKR movement on dsRNA, without sequestering dsRNA, thereby adjusting the activation threshold for long dsRNA.
Nature Communications · Apr 8, 2025Peer-reviewedBiochemistry