An RNase Toxin Hijacks Elongation Factor-Tu to Cleave the Ribosomal Sarcin-Ricin Loop
Julia Takuno Hespanhol, Taylor M Blackburn, Kristi Pham, Akanksha Varshney, Gianlucca Gonçalves Nicastro, Robson F. de Souza, Lakshminarayanan Aravind, Arlen Johnson, Kenneth C. Keiler, Christine M. Dunham, Ethel Bayer‐Santos
This paper characterizes SRLase1, an RNase toxin that cleaves the sarcin-ricin loop of 23S rRNA by repurposing EF-Tu, revealing a new mechanism of ribosome inhibition.
bioRxiv · Sep 19, 2026 · PreprintMicrobiology