Chemical Tools Based on the Tetrapeptide Sequence of IL-18 Reveals Shared Specificities between Inflammatory and Apoptotic Initiator Caspases
Christopher M. Bourne, Nicole R. Raniszewski, Madhura Kulkarni, Patrick M. Exconde, Sherry Liu, Winslow Yost, Tristan J. Wrong, Robert C. Patio, Ashutosh B. Mahale, Matilda Kardhashi, Teni Shosanya, Mirai Kambayashi, Bohdana M. Discher, Igor E. Brodsky, George M. Burslem, Cornelius Y. Taabazuing
The paper develops a new peptide-based inhibitor targeting caspase-8 and reveals shared specificities between inflammatory and apoptotic caspases.
bioRxiv · Feb 23, 2025 · PreprintBiochemistry