Author

Tess M. Deddens

University of Virginia Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Organism:mouse· 1

Frequent Co-Authors

David J. FeithiD· 2 shared Thomas P. LoughraniD· 2 shared Todd E. FoxiD· 2 shared Andrea Joyner· 1 shared Anuradha IllendulaiD· 1 shared Arati K. SharmaiD· 1 shared Ariana SabzevariiD· 1 shared B. Bishal PaudeliD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

David J. FeithORCID

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2 papers

Recent·Most cited

PRECLINICAL DEVELOPMENT OF A ROMIDEPSIN NANOPARTICLE DEMONSTRATES SUPERIOR TOLERABILITY AND EFFICACY IN MODELS OF HUMAN T-CELL LYMPHOMA AND LARGE GRANULAR LYMPHOCYTE LEUKEMIA

Ipsita Pal, Anuradha Illendula, Andrea Joyner, John Sanil Manavalan, Tess M. Deddens, Ariana Sabzevari, Deepthi Priyanka Damera, Samir Zuberi, Enrica Marchi, Todd E. Fox, Marya E. Dunlap-Brown, Kallesh Danappa Jayappa, Jihane Khalife, Jeffrey W. Craig, Thomas P. Loughran, , Owen A. O’Connor

Blood · Sep 2, 2025Peer-reviewedCancer Biology

Acid ceramidase inhibition enhances BCL-2 targeting in venetoclax-resistant acute myeloid leukemia via a cytotoxic integrated stress response

Johnson Ung, Su‐Fern Tan, Jeremy J.P. Shaw, Maansi Taori, Tess M. Deddens, Giovana da Costa Venancio, McLane M. Montgomery, James T. Hagen, Raphael Taiwo Aruleba, Upendarrao Golla, Arati K. Sharma, B. Bishal Paudel, Irene Sung-Ah Lee, Bhavishya U. Ramamoorthy, Kevin A. Janes, , Thomas P. Loughran

This study shows that inhibiting acid ceramidase (AC) enhances venetoclax's effectiveness in venetoclax-resistant AML by inducing a cytotoxic integrated stress response.

bioRxiv · Jun 6, 2025 · PreprintCancer Biology