Kasey S. Love

This paper introduces a miRNA feedback circuit to control synthetic receptor activity, showing tunable and autonomous regulation of synNotch receptor expression.

This study develops high-titer lentiviral vectors for RNA-based gene circuits by optimizing gene syntax and genetic parts to enhance vector production and expression.

The paper shows that gene syntax influences supercoiling-mediated transcriptional feedback, affecting adjacent gene expression in human cells.

DIAL is a framework for designing synthetic promoters that generate heritable, tunable gene expression setpoints across cell types.

The paper designs and characterizes ComMAND, a microRNA-based gene circuit that precisely controls transgene expression in diverse primary cells.

The paper measures mRNA and protein levels in single cells for synthetic promoters, finding that promoter strength affects both transcription and translation, and introduces a framework for comparing gene regulation.