Thomas C. Dix

TET dioxygenases localize at splicing speckles and promote RNA splicing

This study shows TET dioxygenases localize at splicing speckles and promote RNA splicing through interactions with splicing factors and cytosine modifications.

Stochastic splicing and deterministic inclusion of variable exons promote diversification of Down Syndrome Cell Adhesion Molecule expression

The paper investigates stochastic and deterministic mechanisms of Dscam alternative exon inclusion in Drosophila and honey bees, revealing experience-directed splicing patterns.

Memory consolidation in honey bees is enhanced by down-regulation of Down Syndrome Cell Adhesion Molecule and changes its alternative splicing

This study shows that reducing Dscam expression enhances memory retention in honey bees and alters its alternative splicing during memory consolidation.

Structure-optimized sgRNA selection with PlatinumCRISPr for efficient Cas9 generation of knock-outs

The paper develops PlatinumCRISPr, a tool for selecting efficient sgRNAs for CRISPR-Cas9 genome editing, identifies design constraints, and reports unintended DNA insertions from deletions.