Author

Simon A. Jackson

University of AucklandORCID 0000-0002-4512-3093Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Approach:experimental assay· 2 Approach:comparative / phylogenetic analysis· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

Aritz Roa-EguiaraiD· 1 shared Cara R Adolph· 1 shared Cassandra L. Chapman· 1 shared Chase L. BeiseliD· 1 shared Eugene V. KooniniD· 1 shared Franklin L. NóbregaiD· 1 shared Freddie J. O. MartiniD· 1 shared Greg Cook· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperMolecular Biology

Aritz Roa-EguiaraORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

High-throughput genetic interaction analysis in Mycobacterium tuberculosis identifies highly synergistic drug targets

Cassandra L. Chapman, XinYue Wang, Cara R Adolph, Peter C. Fineran, Greg Cook, Simon A. Jackson, Matthew McNeil

This study uses CRISPRi screening in Mycobacterium tuberculosis to identify synergistic drug targets, finding that genetic interactions predict drug-drug synergies and identifying Pks13 as a key synergistic generalist.

bioRxiv · Oct 15, 2026 · PreprintMicrobiology

YprA family helicases provide the missing link between diverse prokaryotic immune systems

Ryan T. Bell, Thomas Gaudin, Yi Wu, Sofya K. Garushyants, Harutyun Sahakyan, Kira S. Makarova, Yuri I. Wolf, Simon A. Jackson, Franklin L. Nóbrega, Chase L. Beisel, Eugene V. Koonin

The paper identifies YprA family helicases as a missing link connecting DISARM and Druantia immune systems in prokaryotes, revealing new defense classes and their antiviral mechanisms.

Cell Host & Microbe · Jun 11, 2026Peer-reviewedMicrobiology

Structure and mechanism of Zorya anti-phage defense system

Haidai Hu, Thomas C.D. Hughes, Philipp F. Popp, Aritz Roa-Eguiara, Freddie J. O. Martin, Nicole R. Rutbeek, Ivo Alexander Hendriks, Leighton J. Payne, Yumeng Yan, Victor Klein-Sousa, Yong Wang, Michael Lund Nielsen, Richard Michael Berry, Marc Erhardt, Simon A. Jackson, Nicholas M. I. Taylor

This study reveals the structure and mechanism of the Zorya anti-phage defense system using cryo-EM and functional assays, showing how it detects phage invasion and activates defense.

bioRxiv · Dec 18, 2023 · PreprintMolecular Biology