Yi Wu

The paper identifies Pucsar, a bacterial antiphage system that uses 3,5-cGMP generated by a cyclase to activate TIR effectors through a stepwise filament assembly process.

The paper identifies YprA family helicases as a missing link connecting DISARM and Druantia immune systems in prokaryotes, revealing new defense classes and their antiviral mechanisms.

This study investigates how Druantia III and Zorya II antiphage defence systems in bacteria synergize through shared DNA intermediates, showing their coordinated response during phage infection.

This study identifies Tmn as a bacterial membrane protein that blocks phage spread by inducing plasmolysis and activates synergistic defence responses through ATP depletion.

The paper identifies a methylome-derived m6-dAMP trigger that forms an immune filament in E. coli to deplete dNTPs and abort phage infection.

The paper introduces KlebPhaCol, a resource containing 53 phages and 74 Klebsiella isolates, including a novel gut phage order, to advance understanding of Klebsiella-phage interactions.

This paper introduces PGGB, a pipeline for building pangenome graphs that includes all variation without bias, enabling variation detection, conservation measurement, recombination event detection, and phylogenetic inference.