Transient reprogramming limits AP-1-associated chromatin opening and transposable element activation to preserve hematopoietic stem cell function during aging and stress
Audrey Porquet, Mathieu Bohm, Hassan Ait-Ougouram, Thu-Ha Trinh, Rabie Chelbi, Mengliang Ye, Ollivier Milhavet, Jean-Marc Lemaı̂tre, Nathalie M Droin, Elina Zueva, Catherine M. Sawai, Emilie Elvira‐Matelot, Françoise Porteu
This study shows that transient reprogramming with Yamanaka factors delays and partially reverses HSC aging and stress-induced decline by limiting AP-1 chromatin opening and transposable element activation.
bioRxiv · Aug 31, 2026 · PreprintCell Biology