CHAMP1 Complex Promotes Heterochromatin Assembly and Reduces Replication Stress
Feng Li, Amira Elbakry, Felix Y. Zhou, Tianpeng Zhang, Ramya Ravindranathan, Huy Nguyen, Aleem Syed, Lifang Sun, Sirisha Mukkavalli, Roger A. Greenberg, Alan D. D’Andrea
This study identifies the CHAMP1 complex as a regulator of heterochromatin assembly and replication fork stability, showing its role in preventing genomic instability in cancer cells.
Proceedings of the National Academy of Sciences · Jan 2, 2026Peer-reviewedMolecular Biology