Sulfonylureas target the neurovascular response to decrease Alzheimer's pathology
Shannon L. Macauley, Molly Stanley, Emily E. Caesar, William R. Moritz, Annie R. Bice, Nildris Cruz‐Diaz, Caitlin M. Carroll, Stephen M. Day, John Grizzanti, Thomas E. Mahan, James Andy Snipes, Timothy E. Orr, Joseph P. Culver, Maria Sara Remedi, Colin G. Nichols, , David M. Holtzman
This study shows that sulfonylureas reduce Alzheimer's pathology by targeting vascular KATP channels, decreasing amyloid-beta aggregation and improving vascular function in mice.
bioRxiv · Aug 11, 2021 · PreprintNeuroscience