Author

Colin G. Nichols

Washington University in St. LouisORCID 0000-0002-4929-2134Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Biochemistry· 1 Developmental Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Caitlin M. CarrolliD· 2 shared Celeste M M. KarchiD· 2 shared David M. HoltzmaniD· 2 shared Emily E. CaesariD· 2 shared James Andy Snipes· 2 shared John Grizzanti· 2 shared Maria Sara RemediiD· 2 shared Molly StanleyiD· 2 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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2 shared papersNeuroscience

Caitlin M. CarrollORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

MgATP/MgADP-dependent conformational dynamics and intrinsically disordered regions of vascular KATP channels revealed by cryoEM

Camden Driggers, Yi‐Ying Kuo, Zhongying Yang, Sun‐Joo Lee, Colin G. Nichols, Katarzyna Walczewska-Szewc, Show‐Ling Shyng

This study uses cryoEM to reveal MgATP/MgADP-dependent conformational changes and IDR organization in vascular KATP channels.

bioRxiv · Sep 29, 2026 · PreprintBiochemistry

A framework to detect positive selection using variant effect predictions reveals widespread adaptive evolution of human neurons

Alexander L. Starr, Michael E. Palmer, Jian Gao, Colin G. Nichols, Hunter B. Fraser

bioRxiv · Sep 11, 2025 · PreprintGenomics

Skeletal dysplasia-causing TRPV4 mutations suppress the hypertrophic differentiation of human iPSC-derived chondrocytes

Amanda R. Dicks, Grigory I. Maksaev, Zainab Harissa, Alireza Savadipour, Ruhang Tang, Nancy S. Steward, Wolfgang Liedtke, Colin G. Nichols, Chia‐Lung Wu, Farshid Guilak

This study investigates how TRPV4 mutations affect chondrocyte differentiation and identifies altered BMP signaling as a mechanism for skeletal dysplasia.

eLife · Feb 13, 2023Peer-reviewedDevelopmental Biology

Kir6.2-containing KATP channels are necessary for glucose dependent increases in amyloid-beta and Alzheimer's-related pathology

John Grizzanti, William R. Moritz, Morgan C. Pait, Molly Stanley, Sarah D. Kaye, Caitlin M. Carroll, Nicholas J. Constantino, Lily J. Deitelzweig, Noelle Isabella Nicol, James Andy Snipes, Derek Kellar, Emily E. Caesar, Jasmeen Dhillon, Maria Sara Remedi, Celeste M M. Karch, , Shannon L. Macauley

This study shows that Kir6.2-KATP channels are necessary for hyperglycemia-induced increases in amyloid-beta and Alzheimer's pathology by regulating lactate transport and Aβ release.

bioRxiv · Feb 20, 2022 · PreprintNeuroscience

Sulfonylureas target the neurovascular response to decrease Alzheimer's pathology

Shannon L. Macauley, Molly Stanley, Emily E. Caesar, William R. Moritz, Annie R. Bice, Nildris Cruz‐Diaz, Caitlin M. Carroll, Stephen M. Day, John Grizzanti, Thomas E. Mahan, James Andy Snipes, Timothy E. Orr, Joseph P. Culver, Maria Sara Remedi, Colin G. Nichols, , David M. Holtzman

This study shows that sulfonylureas reduce Alzheimer's pathology by targeting vascular KATP channels, decreasing amyloid-beta aggregation and improving vascular function in mice.

bioRxiv · Aug 11, 2021 · PreprintNeuroscience