Author

John Grizzanti

Wake Forest University Health Sciences

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Organism:human· 1

Frequent Co-Authors

Caitlin M. CarrolliD· 2 shared Celeste M M. KarchiD· 2 shared Colin G. NicholsiD· 2 shared David M. HoltzmaniD· 2 shared Emily E. CaesariD· 2 shared James Andy Snipes· 2 shared Maria Sara RemediiD· 2 shared Molly StanleyiD· 2 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Caitlin M. CarrollORCID

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2 papers

Recent·Most cited

Kir6.2-containing KATP channels are necessary for glucose dependent increases in amyloid-beta and Alzheimer's-related pathology

John Grizzanti, William R. Moritz, Morgan C. Pait, Molly Stanley, Sarah D. Kaye, Caitlin M. Carroll, Nicholas J. Constantino, Lily J. Deitelzweig, Noelle Isabella Nicol, James Andy Snipes, Derek Kellar, Emily E. Caesar, Jasmeen Dhillon, Maria Sara Remedi, Celeste M M. Karch, , Shannon L. Macauley

This study shows that Kir6.2-KATP channels are necessary for hyperglycemia-induced increases in amyloid-beta and Alzheimer's pathology by regulating lactate transport and Aβ release.

bioRxiv · Feb 20, 2022 · PreprintNeuroscience

Sulfonylureas target the neurovascular response to decrease Alzheimer's pathology

Shannon L. Macauley, Molly Stanley, Emily E. Caesar, William R. Moritz, Annie R. Bice, Nildris Cruz‐Diaz, Caitlin M. Carroll, Stephen M. Day, John Grizzanti, Thomas E. Mahan, James Andy Snipes, Timothy E. Orr, Joseph P. Culver, Maria Sara Remedi, Colin G. Nichols, , David M. Holtzman

This study shows that sulfonylureas reduce Alzheimer's pathology by targeting vascular KATP channels, decreasing amyloid-beta aggregation and improving vascular function in mice.

bioRxiv · Aug 11, 2021 · PreprintNeuroscience