RNA decay via the nuclear exosome is essential for piwi-mediated transposon silencing
Changwei Yu, Toni Manolova, László Tirián, Dominik Handler, Ulrich Hohmann, Filip Nemčko, Júlia Portell i de Montserrat, Guillaume Giraud Collet, Jakob Schnabl, Ellie Blake, Peter Duchek, Maria Novatchkova, Elisabeth Roitinger, Felipe Karam Teixeira, Sebastian Falk, Julius Brennecke
The paper shows that the Drosophila Piwi-piRNA pathway silences transposons by degrading their RNA via the nuclear exosome, with TEsup proteins facilitating this process.
bioRxiv · Dec 16, 2025 · PreprintMolecular Biology