A nuclear receptor facilitates differentiation of human PSCs into more mature hepatocytes
Haiting Ma, Esmée de Zwaan, Yang Eric Guo, Paloma Cejas, Prathapan Thiru, Martijn van de Bunt, Jacob Fuglsbjerg Jeppesen, Sudeepa Syamala, Alessandra Dall’Agnese, Brian J. Abraham, Dongdong Fu, Carrie M. Garrett-Engele, Tony Lee, Henry W. Long, Linda Gay Griffith, , Rudolf Jaenisch
This study identifies thyroid hormone receptor THRB as a key regulator of hepatocyte maturation from human PSCs, showing that T3 treatment enhances gene expression and epigenetic features of mature hepatocytes.
bioRxiv · Mar 24, 2022 · PreprintDevelopmental Biology