Mitochondrial instability contributes to IFN-driven heart disease.
Arati Naveen Kumar, Amelia Meecham, Deepika Rai, Brennan Kandalaft, Trinitee Oliver, Aleksandr B. Stotland, Asli E. Atici, Magali Novas Rivas, Richard I. Ainsworth, Megan Laura McCain, Sarah J. Parker, Caroline Anne Jefferies
This study shows chronic IFN exposure impairs heart function by causing mitochondrial stress, mtDNA release, and a self-sustaining inflammatory loop in cardiomyocytes.
bioRxiv · Sep 15, 2025 · PreprintImmunology