Megan Laura McCain

Human iPSC-Derived Cardiomyocytes Maladaptively Remodel to Cyclic Stretch in Hypoplastic Left Heart Syndrome

This study compares how HLHS patient-derived iPSC-CMs and control iPSC-CMs respond to cyclic stretch, finding impaired mechanoadaptation and heightened inflammation in HLHS cells.

Mitochondrial instability contributes to IFN-driven heart disease.

This study shows chronic IFN exposure impairs heart function by causing mitochondrial stress, mtDNA release, and a self-sustaining inflammatory loop in cardiomyocytes.

Human iPSC-derived motor neuron innervation enhances the differentiation of muscle bundles engineered with benchtop fabrication techniques

This study shows that adding human iPSC-derived motor neurons to engineered muscle bundles improves their structural and functional maturity and maintains an oxidative phenotype.

Engineering Programmable Material-To-Cell Pathways Via Synthetic Notch Receptors To Spatially Control Cellular Phenotypes In Multi-Cellular Constructs

The paper develops synthetic Notch receptor-based material-to-cell signaling pathways to spatially control cellular phenotypes in multicellular constructs.

Identification of Disease-relevant, Sex-based Proteomic Differences in iPSC-derived Vascular Smooth Muscle

This study identifies sex-based proteomic differences in iPSC-derived vascular smooth muscle cells and their potential impact on cardiovascular disease.

Heterogeneous pdgfrβ+ cells regulate coronary vessel development and revascularization during heart regeneration

The paper identifies heterogeneous pdgfrβ+ cells critical for coronary vessel development and heart regeneration in zebrafish.