FGF19 and its analog Aldafermin cooperate with MYC to induce aggressive hepatocarcinogenesis
J. Ursic-Bedoya, G. Desandre, C. Chavey, P. Marie, A. Polizzi, B. Riviere, H. Guillou, E. Assenat, U. Hibner, D. Gregoire
This study shows that FGF19 and its analog Aldafermin cooperate with MYC to drive aggressive hepatocarcinogenesis in mice, raising concerns about the safety of Aldafermin in patients with compromised livers.
bioRxiv · Sep 15, 2023Cancer Biology