Author

U. Santiago

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:proteomics· 3 Approach:statistical model· 3 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

C. J. Camacho· 4 shared G. Calero· 2 shared K. A. Paris· 2 shared S. Vergara· 2 shared A. Chen· 1 shared B. Hu· 1 shared C. Jin· 1 shared D. Schneidman-Duhovny· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersBiophysics

C. J. Camacho

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Structures of kinetic intermediate states of HIV-1 reverse transcriptase DNA synthesis

S. Vergara, X. Zhou, U. Santiago, J. F. Conway, N. Sluis-Cremer, G. Calero

This study captures 11 structures of HIV-1 reverse transcriptase during DNA synthesis, revealing intermediate states and mechanisms of dATP incorporation and drug resistance.

bioRxiv · Dec 18, 2023 · PreprintBiophysics

Omicron and Alpha P680H block SARS-CoV2 spike protein from accessing cholinergic inflammatory pathway via α9-nAChR mitigating the risk of MIS-C

C. J. Camacho, U. Santiago

The paper shows that Omicron and Alpha variants of SARS-CoV-2 reduce cytokine release via α9-nAChR by altering the spike protein's furin cleavage site, potentially lowering the risk of MIS-C.

bioRxiv · Feb 18, 2022 · PreprintBiophysics

A robust and versatile nanobody platform for drug delivery

Z. Shen, Y. Xiang, S. Vergara, A. Chen, Z. Xiao, U. Santiago, C. Jin, Z. Sang, J. Luo, K. Chen, D. Schneidman-Duhovny, C. J. Camacho, G. Calero, B. Hu, Y. Shi

This paper develops a nanobody platform for drug delivery, showing improved pharmacokinetics and therapeutic efficacy of NbHSA conjugates.

bioRxiv · Aug 19, 2020 · PreprintBioengineering

On the molecular mechanism of SARS-CoV-2 retention in the upper respiratory tract

K. A. Paris, U. Santiago, C. J. Camacho

This study identifies a pH-dependent receptor binding mechanism in SARS-CoV-2 that enhances ACE2 receptor retention, leading to prolonged viral shedding and transmission.

bioRxiv · Jul 29, 2020 · PreprintBiophysics

Loss of pH switch unique to SARS-CoV2 supports unfamiliar virus pathology

C. J. Camacho, K. A. Paris, U. Santiago

This paper analyzes the pH-switch difference between SARS-CoV1 and SARS-CoV2, showing how the loss of this switch in CoV2 allows prolonged ACE2 receptor binding, contributing to higher transmission and pathogenicity.

bioRxiv · Jun 16, 2020 · PreprintBiophysics