Author

G. Calero

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:structural biology· 3 Research Focus:drug response / drug discovery· 2 Research Focus:protein structure prediction· 2 Assay:proteomics· 2 Research Focus:chromatin & epigenetic regulation· 1 Organism:E. coli· 1 Organism:human· 1

Frequent Co-Authors

A. E. Cohen· 2 shared C. O. Barnes· 2 shared J. Song· 2 shared S. Vergara· 2 shared U. Santiago· 2 shared A. Chen· 1 shared A. Holmes· 1 shared A. Lyubimov· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBiophysics

A. E. Cohen

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Structures of kinetic intermediate states of HIV-1 reverse transcriptase DNA synthesis

S. Vergara, X. Zhou, U. Santiago, J. F. Conway, N. Sluis-Cremer, G. Calero

This study captures 11 structures of HIV-1 reverse transcriptase during DNA synthesis, revealing intermediate states and mechanisms of dATP incorporation and drug resistance.

bioRxiv · Dec 18, 2023 · PreprintBiophysics

Structural basis of transcription: RNA Polymerase II substrate binding and metal coordination at 3.0 A using a free-electron laser

L. Guowu, C. O. Barnes, S. Weiss, B. Dutagaci, C. Qiu, M. Feig, A. Lyubimov, J. Song, A. E. Cohen, C. D. Kaplan, G. Calero

This paper presents the structure of ATP-bound RNA Polymerase II at 3.0 Å resolution using a free-electron laser, revealing new insights into substrate binding and metal coordination in the active site.

bioRxiv · Sep 22, 2023 · PreprintBiophysics

Discovery of a novel human antibody VH domain with potent activity against mesothelin expressing cancer cells in both CAR T-cell and antibody drug conjugate formats

Z. Sun, X. Chu, C. Adams, T. V. Ilina, C. Chen, D. Jelev, R. Ishima, W. Li, J. W. Mellors, G. Calero, D. S. Dimitrov

The paper identifies a novel human antibody VH domain with high affinity for mesothelin and demonstrates its efficacy in both CAR-T cell and antibody drug conjugate formats against mesothelin-expressing cancer cells.

bioRxiv · Apr 7, 2022 · PreprintCancer Biology

A robust and versatile nanobody platform for drug delivery

Z. Shen, Y. Xiang, S. Vergara, A. Chen, Z. Xiao, U. Santiago, C. Jin, Z. Sang, J. Luo, K. Chen, D. Schneidman-Duhovny, C. J. Camacho, G. Calero, B. Hu, Y. Shi

This paper develops a nanobody platform for drug delivery, showing improved pharmacokinetics and therapeutic efficacy of NbHSA conjugates.

bioRxiv · Aug 19, 2020 · PreprintBioengineering

Molecular mimicry in deoxy-nucleotide catalysis: the structure of Escherichia coli dGTPase reveals the molecular basis of dGTP selectivity

C. O. Barnes, Y. Wu, J. Song, G. Lin, E. L. Baxter, A. S. Brewster, V. Nagarajan, A. Holmes, M. Soltis, J. Ahn, A. E. Cohen, G. Calero

This paper determines the structure of Escherichia coli dGTPase and elucidates the molecular basis of its dGTP selectivity through comparative analysis with SAMHD1.

bioRxiv · Nov 29, 2018 · PreprintBiophysics