PIEZO channels link mechanical forces to uterine contractions in parturition
Yunxiao Zhang, Sejal A Kini, Sassan A Mishkanian, Renhao Luo, Saba Heydari Seradj, Verina H. Leung, Yu Wang, M. Rocio Servin‐Vences, William Thomas Keenan, Utku Sonmez, Oleg Yarishkin, Manuel Sánchez-Alavez, Yuejia Liu, Xin Jin, Darren J. Lipomi, , Ardem Patapoutian
Deleting Piezo1 and Piezo2 together in mice weakens uterine contractions and prolongs labor; uterine and sensory-neuron deletions act additively, and knockout uteri show reduced Gja1 (connexin43).
Science · Nov 13, 2025Peer-reviewedPhysiology✦ In-depth digest