Author

V. Irizarry-Negron

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

F. Bednar· 2 shared K. L. Brown· 2 shared K. L. Donahue· 2 shared M. Pasca di Magliano· 2 shared N. G. Steele· 2 shared R. E. Menjivar· 2 shared S. B. Kemp· 2 shared W. Du· 2 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

F. Bednar

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Author profile →

2 papers

Recent·Most cited

Notch signaling regulates immunosuppressive tumor-associated macrophage function in pancreatic cancer

W. Yan, N. G. Steele, S. B. Kemp, R. E. Menjivar, W. Du, E. S. Carpenter, K. L. Donahue, K. L. Brown, V. Irizarry-Negron, S. Yang, W. R. Burns, Y. Zhang, M. Pasca di Magliano, F. Bednar

This study shows Notch signaling in tumor-associated macrophages promotes immunosuppression in pancreatic cancer, and blocking it enhances immune therapy effectiveness.

bioRxiv · Jan 11, 2023Cancer Biology

Extrinsic KRAS signaling shapes the pancreatic microenvironment through fibroblast reprogramming.

A. Velez-Delgado, K. L. Donahue, K. L. Brown, W. Du, V. Irizarry-Negron, R. E. Menjivar, E. L. Lasse-Opsahl, N. G. Steele, S. The, J. Lazarus, V. R. Sirihorachai, W. Yan, S. B. Kemp, S. A. Kerk, M. Bollamplly, , M. Pasca di Magliano

This study shows that extrinsic KRAS signaling reprograms pancreatic fibroblasts to create an inflammatory microenvironment that supports tumor growth.

bioRxiv · Aug 26, 2021Cancer Biology