Author

R. E. Menjivar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Organism:mouse· 3 Approach:statistical model· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

C. A. Lyssiotis· 4 shared M. Pasca di Magliano· 4 shared F. Bednar· 3 shared W. Du· 3 shared W. Yan· 3 shared Y. Zhang· 3 shared Z. C. Nwosu· 3 shared C. J. Halbrook· 2 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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4 shared papersCancer Biology

C. A. Lyssiotis

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5 papers

Recent·Most cited

Notch signaling regulates immunosuppressive tumor-associated macrophage function in pancreatic cancer

W. Yan, N. G. Steele, S. B. Kemp, R. E. Menjivar, W. Du, E. S. Carpenter, K. L. Donahue, K. L. Brown, V. Irizarry-Negron, S. Yang, W. R. Burns, Y. Zhang, M. Pasca di Magliano, F. Bednar

This study shows Notch signaling in tumor-associated macrophages promotes immunosuppression in pancreatic cancer, and blocking it enhances immune therapy effectiveness.

bioRxiv · Jan 11, 2023Cancer Biology

Arginase 1 is a key driver of immune suppression in pancreatic cancer

R. E. Menjivar, Z. C. Nwosu, W. Du, K. Donahue, C. Espinoza, K. Brown, A. Velez, W. Yan, F. Lima, A. Bischoff, P. Kadiyala, D. Salas-Escabillas, C. J. Halbrook, F. Bednar, E. Carpenter, , M. di Magliano

This study shows that Arginase 1 suppresses immune responses in pancreatic cancer by inhibiting T cell activation, and targeting it enhances immunotherapy effectiveness.

bioRxiv · Jun 21, 2022Cancer Biology

Extrinsic KRAS signaling shapes the pancreatic microenvironment through fibroblast reprogramming.

A. Velez-Delgado, K. L. Donahue, K. L. Brown, W. Du, V. Irizarry-Negron, R. E. Menjivar, E. L. Lasse-Opsahl, N. G. Steele, S. The, J. Lazarus, V. R. Sirihorachai, W. Yan, S. B. Kemp, S. A. Kerk, M. Bollamplly, , M. Pasca di Magliano

This study shows that extrinsic KRAS signaling reprograms pancreatic fibroblasts to create an inflammatory microenvironment that supports tumor growth.

bioRxiv · Aug 26, 2021Cancer Biology

Nutrient profiling reveals extracellular uridine as a fuel for pancreatic cancer through uridine phosphorylase 1

M. H. Ward, Z. C. Nwosu, P. Poudel, S. Kasperek, Z. Tolstyka, R. E. Menjivar, C. Ragulan, G. Nyamundanda, L. Zhang, A. Andren, C. J. Halbrook, E. S. Carpenter, M. Pasca di Magliano, A. Sadanandam, C. A. Lyssiotis

This study identifies uridine as a novel nutrient for pancreatic cancer cells through uridine phosphorylase 1, showing its role in survival and metabolism under glucose deprivation.

bioRxiv · Jun 7, 2021 · PreprintCancer Biology

Multi-dimensional analyses identify genes of high priority for pancreatic cancer research

Z. C. Nwosu, H. Giza, M. Nassif, V. Charlestin, R. E. Menjivar, D. Kim, S. Kemp, N. Steele, J. Hu, B. Hu, S. Wang, M. Pasca di Magliano, C. A. Lyssiotis

The paper identifies consistently expressed genes in pancreatic ductal adenocarcinoma (PDAC) to prioritize therapeutic targets and biomarkers.

bioRxiv · May 28, 2021 · PreprintCancer Biology