Author

N. G. Steele

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 6

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Approach:experimental assay· 6 Organism:mouse· 6 Research Focus:cell type annotation· 4 Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Approach:statistical model· 2

Frequent Co-Authors

H. C. Crawford· 4 shared M. Pasca di Magliano· 4 shared F. Bednar· 3 shared H.-J. Wen· 3 shared S. B. Kemp· 3 shared Y. Zhang· 3 shared C. A. Lyssiotis· 2 shared D. Long· 2 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersCancer Biology

H. C. Crawford

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6 papers

Recent·Most cited

Tuft cells transdifferentiate to neural-like progenitor cells in the progression of pancreatic cancer

D. J. Salas-Escabillas, M. T. Hoffman, J. S. Moore, S. M. Brender, H.-J. Wen, S. Benitz, E. T. Davis, D. Long, A. M. Wombwell, N. G. Steele, R. C. Sears, I. Matsumoto, K. E. DelGiorno, H. C. Crawford

The paper shows that metaplastic tuft cells in pancreatic cancer transdifferentiate into neural-like progenitor cells, driven by Myc activity, and this transition is linked to poor patient survival.

bioRxiv · Feb 12, 2024Cancer Biology

ROR2 regulates cellular plasticity in pancreatic neoplasia and adenocarcinoma

S. Benitz, A. Steep, M. Nasser, J. Preall, U. M. Mahajan, H. McQuithey, I. Loveless, E. T. Davis, H.-J. Wen, D. W. Long, T. Metzler, S. Zwernik, M. Louw, D. Rempinski, D. Salas-Escabillas, , H. C. Crawford

This study identifies ROR2 as a regulator of cellular plasticity in pancreatic neoplasia, showing it promotes an aggressive PDAC phenotype and resistance to KRAS inhibitors.

bioRxiv · Dec 13, 2023Cancer Biology

Modeling Molecular Pathogenesis of Idiopathic Pulmonary Fibrosis-Associated Lung Cancer in Mice

I. Barravecchia, J. M. Lee, J. Manassa, B. Magnuson, S. Cavanaugh, N. G. Steele, C. Espinoza, C. J. Galban, N. Ramnath, T. L. Frankel, M. Pasca di Magliano, S. Galban

This study develops a mouse model to investigate how IPF-related fibrosis influences lung cancer development and identifies immune-suppressive mechanisms and therapeutic targets.

bioRxiv · Jun 20, 2023Cancer Biology

Notch signaling regulates immunosuppressive tumor-associated macrophage function in pancreatic cancer

W. Yan, N. G. Steele, S. B. Kemp, R. E. Menjivar, W. Du, E. S. Carpenter, K. L. Donahue, K. L. Brown, V. Irizarry-Negron, S. Yang, W. R. Burns, Y. Zhang, M. Pasca di Magliano, F. Bednar

This study shows Notch signaling in tumor-associated macrophages promotes immunosuppression in pancreatic cancer, and blocking it enhances immune therapy effectiveness.

bioRxiv · Jan 11, 2023Cancer Biology

Extrinsic KRAS signaling shapes the pancreatic microenvironment through fibroblast reprogramming.

A. Velez-Delgado, K. L. Donahue, K. L. Brown, W. Du, V. Irizarry-Negron, R. E. Menjivar, E. L. Lasse-Opsahl, N. G. Steele, S. The, J. Lazarus, V. R. Sirihorachai, W. Yan, S. B. Kemp, S. A. Kerk, M. Bollamplly, , M. Pasca di Magliano

This study shows that extrinsic KRAS signaling reprograms pancreatic fibroblasts to create an inflammatory microenvironment that supports tumor growth.

bioRxiv · Aug 26, 2021Cancer Biology

The Pancreatic Tumor Microenvironment Compensates for Loss of GOT2

S. A. Kerk, L. Lin, A. L. Myers, Y. Zhang, J. A. Jimenez, P. Sajjakulnukit, B. S. Nelson, B. Chen, A. Robinson, G. Thurston, S. B. Kemp, N. G. Steele, M. T. Hoffman, H.-J. Wen, D. Long, , C. A. Lyssiotis

This study shows that the pancreatic tumor microenvironment compensates for loss of GOT2 by providing pyruvate, maintaining redox homeostasis and tumor growth in vivo.

bioRxiv · Aug 7, 2020Cancer Biology