V. Molle

The Secreted Tyrosine Phosphatase PtpA promotes Staphylococcus aureus Intramacrophagic Survival Through Decrease of the SUMOylation Host Response

This study identifies PtpA as a secreted phosphatase that reduces host SUMOylation by lowering Ubc9 levels, enhancing S. aureus survival during long-term infection.

Druggable redox pathways against M. abscessus in cystic fibrosis patient-derived airway organoids

This study uses airway organoids to investigate M. abscessus infection in CF patients, showing antioxidant pathways can inhibit bacterial growth and enhance antibiotic efficacy.

Investigating pathogenicity and virulence of Staphylococcus pettenkoferi: an emerging pathogen

This study compares the pathogenicity of Staphylococcus pettenkoferi to Staphylococcus aureus using in vitro, ex vivo, and in vivo assays, revealing its ability to survive in human cells and cause zebrafish embryo mortality.

Cancer cell hyper-proliferation disrupts the topological invariance of epithelial monolayers

This study shows that cancer cell hyper-proliferation disrupts the topological order of epithelial monolayers, leading to random structures, while non-tumoral epithelia maintain ordered configurations.

A divergent CheW confers plasticity to nucleoid-associated chemosensory arrays

The paper identifies FrzB, a divergent CheW in M. xanthus, which lacks the CheA-interacting region and functions upstream of FrzCD to enable distributed chemosensory arrays on the nucleoid, conferring plasticity to chemosensory systems.

The Coxiella burnetii secreted protein kinase CstK influences vacuole development and interacts with the GTPase-activating protein TBC1D5

This study identifies CstK, a Coxiella burnetii kinase, as an effector that interacts with TBC1D5 to regulate vacuole formation and intracellular replication.

The nucleoid as a scaffold for the assembly of bacterial signaling complexes

The paper shows that FrzCD chemoreceptors bind the bacterial nucleoid non-sequence-specifically, forming distributed clusters that enable cooperative signaling.

A gated relaxation oscillator controls morphogenetic movements in bacteria

The paper identifies a gated relaxation oscillator mechanism in Myxococcus xanthus that controls polarity reversals through FrzX and RomR, enabling tunable motility responses.