P. Gayathri

RomX, a novel prokaryotic regulator, links the response receiver domain of RomR with GTP-bound MglA for establishing Myxococcus xanthus polarity

This study determines the crystal structure of RomX, a novel prokaryotic regulator, and shows it interacts with MglA-GTP and RomR-REC domains to regulate MglA localization in Myxococcus xanthus.

Insights into assembly of constitutive filament-forming proteins of novel fold through domain dissection and EGFP insertion-based screen: A case study of Spiroplasma Fibril

The paper identifies minimal domains required for Fibril polymerization using domain dissection and EGFP insertion-based screening in Spiroplasma.

An amphipathic helix facilitates direct membrane binding of Mycoplasma FtsZ

This study identifies a novel amphipathic helix in mycoplasma FtsZ that enables direct membrane binding, offering insights into Z-ring constriction in cell wall-less bacteria.

Mechanism of GTPase activation of a prokaryotic small Ras-like GTPase MglA by an asymmetrically interacting MglB dimer

This study investigates how the asymmetric interaction of MglB dimer regulates GEF and GAP activities of MglA, revealing an allosteric mechanism for GEF action.

Dynamics of interdomain rotation facilitates FtsZ filament assembly

This study investigates FtsZ assembly dynamics by analyzing SmFtsZ from Spiroplasma melliferum, showing that interdomain rotation is a rate-limiting step in polymerization.

A salt bridge-mediated resistance mechanism to FtsZ inhibitor PC190723 revealed by a cell-based screen

This paper develops a cell-based assay to screen for FtsZ inhibitors and identifies a salt bridge-mediated resistance mechanism to PC190723 in Helicobacter pylori FtsZ.

Characterization of heterologously expressed fibril filaments, a shape and motility determining cytoskeletal protein of the helical bacterium Spiroplasma

This study characterizes fibril, a cytoskeletal protein in Spiroplasma, showing it forms filament bundles and has both α-helical and β-sheet structures, suggesting a non-amyloid-like assembly mechanism.

Filament dynamics driven by ATP hydrolysis modulates membrane binding of the bacterial actin MreB

This study shows that ATP hydrolysis modulates MreB filament dynamics and membrane binding, affecting filament length, bundling, and curvature-dependent orientation.

Genetic interaction between profilin and myosin II reveals a potential role for myosin II in actin filament disassembly in vivo

The paper identifies a genetic interaction between profilin and myosin II in fission yeast, suggesting myosin II's role in actin filament disassembly and turnover.

Transcriptome responses of intestinal epithelial cells induced by membrane vesicles of Listeria monocytogenes unveil novel insights into the host-pathogen cross talk

This study examines how Listeria monocytogenes membrane vesicles alter host cell transcriptomes, revealing pathways involved in immune evasion and host cell survival.

The nucleoid as a scaffold for the assembly of bacterial signaling complexes

The paper shows that FrzCD chemoreceptors bind the bacterial nucleoid non-sequence-specifically, forming distributed clusters that enable cooperative signaling.