C. Ferguson

Extended Nucleic Acid (exNA): A Novel, Biologically Compatible Backbone that Significantly Enhances Oligonucleotide Efficacy in vivo

This paper introduces exNA, a novel nucleic acid backbone that enhances oligonucleotide stability and efficacy in vivo, showing improved resistance to exonucleases and increased tissue exposure and potency.

A role for caveolar proteins in regulation of the circadian clock

This study shows that cavin proteins modulate the circadian clock by interacting with PER2 and responding to stimuli like oxidative stress and calcium influx.

Mechanical and Heat Hyperalgesia upon Withdrawal from Chronic Intermittent Ethanol Vapor depends on Sex, Exposure Duration and Blood Alcohol Concentration in Mice

This study examines sex, BAC, and time-dependent mechanical and heat hyperalgesia in a mouse model of chronic alcohol withdrawal induced pain.

Caveolae respond to acute oxidative stress through membrane lipid peroxidation, cytosolic release of CAVIN1, and downstream regulation of NRF2

This study shows that caveolae regulate oxidative stress response by lipid peroxidation, CAVIN1 release, and NRF2 interaction, affecting cell death and regeneration.

Muscle-specific Cavin4 interacts with Bin1 to promote T-tubule formation and stability in developing skeletal muscle

This study identifies Cavin4's role in T-tubule formation and stability in skeletal muscle by showing its interaction with Bin1 and effects on caveolae remodeling.

APEX-Gold: A genetically-encoded particulate marker for robust 3D electron microscopy

APEX-Gold converts APEX reaction products into silver/gold particles for improved EM detection of tagged proteins.

An inverted Caveolin-1 topology defines a novel exosome secreted from prostate cancer cells

The paper identifies an inverted Cav1 topology in exosomes secreted by prostate cancer cells, revealing a non-canonical autophagy pathway involved in disease progression.

Drug-induced increase in lysobisphosphatidic acid reduces the cholesterol overload in Niemann-Pick type C cells and mice

The paper identifies thioperamide as a drug that increases lysobisphosphatidic acid (LBPA) levels, reducing cholesterol overload in Niemann-Pick type C cells and mice.

Rab5 and Alsin regulate stress-activated cytoprotective signaling on mitochondria

The paper identifies a novel pathway involving Rab5 and Alsin that regulates stress-activated cytoprotective signaling on mitochondria, linking mitochondrial stress response to ALS pathology.