Author

N. Yamada

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Immunology· 1 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1

Frequent Co-Authors

A. Khvorova· 1 shared A. Oishi· 1 shared A. Summer· 1 shared B. Bramato· 1 shared B. Godinho· 1 shared C. Baatarjav· 1 shared C. Ferguson· 1 shared C. Lochmann· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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1 shared paperBiochemistry

A. Khvorova

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Extended Nucleic Acid (exNA): A Novel, Biologically Compatible Backbone that Significantly Enhances Oligonucleotide Efficacy in vivo

K. Yamada, V. N. Hariharan, J. Caiazzi, R. Miller, C. Ferguson, E. Sapp, H. Fakih, Q. Tan, N. Yamada, R. Furgal, J. Paquette, B. Bramato, N. McHugh, A. Summer, C. Lochmann, , A. Khvorova

This paper introduces exNA, a novel nucleic acid backbone that enhances oligonucleotide stability and efficacy in vivo, showing improved resistance to exonucleases and increased tissue exposure and potency.

bioRxiv · May 26, 2023Biochemistry

Cryo-sensitive aggregation triggers NLRP3 inflammasome assemblyin cryopyrin-associated periodic syndrome

T. Karasawa, T. Komada, N. Yamada, E. Aizawa, Y. Mizushina, S. Watanabe, C. Baatarjav, T. Matsumura, M. Takahashi

This study identifies cryo-sensitive NLRP3 aggregates as a scaffold for inflammasome activation in CAPS, showing Ca2+ influx is essential for this process.

eLife · May 26, 2022Peer-reviewedImmunology

The PfAP2-G2 transcription factor is a critical regulator of gametocyte maturation

S. Singh, J. M. Santos, L. M. Orchard, N. Yamada, R. van Biljon, H. J. Painter, S. Mahony, M. Llinas

This study identifies PfAP2-G2 as a critical transcription factor for Plasmodium falciparum gametocyte maturation, showing it regulates gene expression and interacts with chromatin remodeling proteins.

bioRxiv · Oct 27, 2020Microbiology

Enterohepatic transcription factor CREB3L3 protects atherosclerosis via SREBP competitive inhibition

H. Shimano, Y. Nakagawa, Y. Yunong Wang, S.-i. Han, K. Okuda, A. Oishi, Y. Yagishita, K. Kumagai, H. Ohno, Y. Osaki, Y. Mizunoe, Y. Murayama, H. Iwasaki, M. Konishi, N. Itoh, , M. Araki

This study shows CREB3L3 protects against atherosclerosis by inhibiting SREBP activity through competitive antagonism, reducing lipogenic and cholesterogenic gene expression.

bioRxiv · Apr 29, 2020Physiology