Author

V. Pascual

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Organism:human· 5 Approach:statistical model· 5 Assay:bulk RNA-seq· 4 Research Focus:differential expression· 4 Research Focus:gene regulatory network inference· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

D. Nehar-Belaid· 3 shared J. Banchereau· 3 shared A. Mejias· 2 shared A. O'Garra· 2 shared C. Bloom· 2 shared C. M. Graham· 2 shared D. Chaussabel· 2 shared D. Ucar· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersImmunology

D. Nehar-Belaid

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

An unconventional mechanism of IL-1β secretion that requires Type I IFN in lupus monocytes

S. Caielli, P. Balasubramanian, J. Rodriguez-Alcazar, U. Balaji, Z. Wan, J. Baisch, C. Smitherman, L. Walters, P. Sparagana, D. Nehar-Belaid, R. Marches, L. Nassi, K. Stewart, J. Fuller, J. F. Banchereau, , V. Pascual

The paper identifies an unconventional IL-1β secretion mechanism in lupus monocytes requiring Type I IFN, involving mitochondrial RNA and the NLRP3 inflammasome.

bioRxiv · Aug 3, 2023 · PreprintImmunology

Epigenetic Memory of COVID-19 in Innate Immune Cells and Their Progenitors

J. G. Cheong, A. Ravishankar, S. Sharma, C. Parkhurst, D. Nehar-Belaid, S. Ma, L. Paddock, B. Fatou, E. Karakaslar, A. Thibodeau, M. Bale, V. Kartha, J. Yee, M. Y. Mays, L. Leyre, , S. Josefowicz

The paper identifies sustained epigenomic changes in hematopoietic stem and progenitor cells after COVID-19, which influence innate immune cell function and inflammation.

bioRxiv · Feb 9, 2022Immunology

Single cell analysis of blood mononuclear cells stimulated through CD3 and CD28 shows collateral activation of B and NK cells and demise of monocytes

N. T. Lawlor, D. Nehar-Belaid, J. Grassmann, M. Stoeckius, P. Smibert, M. L. Stitzel, V. Pascual, J. Banchereau, A. Williams, D. Ucar

The paper uses single-cell RNA-seq and CITE-seq to analyze PBMC responses to T-cell and monocyte activators, showing differential activation patterns and transcriptional changes in various immune cell types.

bioRxiv · Dec 23, 2020 · PreprintImmunology

Development and Characterization of a Fixed Repertoire of Blood Transcriptome Modules Based on Co-expression Patterns Across Immunological States

M. C. Altman, D. Rinchai, N. Baldwin, M. Toufiq, E. Whalen, M. Garand, B. A. Kabeer, M. Alfaki, S. Presnell, P. Khaenam, A. A. Benitez, F. Mougin, P. Thebault, L. Chiche, N. Jourde-Chiche, , D. Chaussabel

The paper develops a fixed repertoire of blood transcriptome modules based on co-expression patterns across immunological states to provide a stable framework for analyzing and interpreting blood transcriptome data.

bioRxiv · Apr 28, 2020Immunology

A Transcriptome Fingerprinting Assay for Clinical Immune Monitoring

M. C. Altman, N. Baldwin, E. Whalen, T. Al-Shaikhly, S. Presnell, P. Khaenam, V. H. Gersuk, L. Chiche, N. Jourde-Chiche, T. Phillips, G. Klintmalm, A. O'Garra, M. Berry, C. Bloom, R. J. Wilkinson, , D. Chaussabel

The paper develops a targeted transcriptome fingerprinting assay using modular transcriptional repertoires to assess immune functions in clinical settings.

bioRxiv · Mar 24, 2019 · PreprintImmunology