Author

V. S. Boorla

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 3 Research Focus:drug response / drug discovery· 3 Organism:human· 3 Assay:proteomics· 2 Research Focus:host-pathogen & immune response· 1 Organism:non-human primate· 1 Assay:protein sequence· 1 Assay:protein structure· 1

Frequent Co-Authors

C. D. Maranas· 3 shared R. Chowdhury· 3 shared A. Gontu· 2 shared C. Chen· 2 shared R. H. Nissly· 2 shared S. V. Kuchipudi· 2 shared D. Banerjee· 1 shared K. J. Vandegrift· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersBiophysics

C. D. Maranas

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Author profile →

3 papers

Recent·Most cited

A CNN model for predicting binding affinity changes between SARS-CoV-2 spike RBD variants and ACE2 homologues

C. Chen, V. S. Boorla, R. Chowdhury, R. H. Nissly, A. Gontu, S. K. Chothe, L. LaBella, P. Jakka, S. Ramasamy, K. J. Vandegrift, M. Surendran Nair, S. V. Kuchipudi, C. D. Maranas

The paper introduces a CNN model to predict RBD-hACE2 binding affinity changes for SARS-CoV-2 variants, achieving high accuracy and identifying variants with improved binding affinity.

bioRxiv · Mar 22, 2022 · PreprintBiophysics

Computational prediction of the effect of amino acid changes on the binding affinity between SARS-CoV-2 spike protein and the human ACE2 receptor

C. Chen, V. S. Boorla, D. Banerjee, R. Chowdhury, V. S. Cavener, R. H. Nissly, A. Gontu, N. R. Boyle, K. Vandegrift, M. S. Nair, S. V. Kuchipudi, C. D. Maranas

The paper predicts the effect of amino acid changes on SARS-CoV-2 spike protein binding to hACE2 using molecular dynamics and a neural network, achieving 82.2% classification accuracy and 0.69 correlation with experimental data.

bioRxiv · Mar 24, 2021Biophysics

De novo design of high-affinity antibody variable regions (Fv) against the SARS-CoV-2 spike protein

V. S. Boorla, R. Chowdhury, C. D. Maranas

This paper designs high-affinity antibodies against SARS-CoV-2 spike protein using computational methods and reports on top designs with balanced affinity and immunogenicity.

bioRxiv · Apr 9, 2020Immunology