R. H. Nissly

A CNN model for predicting binding affinity changes between SARS-CoV-2 spike RBD variants and ACE2 homologues

The paper introduces a CNN model to predict RBD-hACE2 binding affinity changes for SARS-CoV-2 variants, achieving high accuracy and identifying variants with improved binding affinity.

Detection of SARS-CoV-2 Omicron variant (B.1.1.529) infection of white-tailed deer

The paper shows SARS-CoV-2 Omicron variant infects white-tailed deer on Staten Island, with age-dependent antibody prevalence and evidence of human-to-deer spillover.

Multiple spillovers and onward transmission of SARS-Cov-2 in free-living and captive White-tailed deer

SARS-CoV-2 was detected in one-third of sampled white-tailed deer in Iowa between September 2020 and January of 2021 that likely resulted from multiple human-to-deer spillover and deer-to-deer transmission events.

Computational prediction of the effect of amino acid changes on the binding affinity between SARS-CoV-2 spike protein and the human ACE2 receptor

The paper predicts the effect of amino acid changes on SARS-CoV-2 spike protein binding to hACE2 using molecular dynamics and a neural network, achieving 82.2% classification accuracy and 0.69 correlation with experimental data.

Influenza C and D viral load in cattle correlates with bovine respiratory disease (BRD): Emerging role of orthomyxoviruses in the pathogenesis of BRD

This study investigates the association between influenza C and D viral loads and bovine respiratory disease in cattle, finding higher viral loads and coinfections in BRD-symptomatic animals.

Limited window for donation of convalescent plasma with high live-virus neutralizing antibodies for COVID-19 immunotherapy

The study evaluates anti-SARS-CoV-2 antibody and neutralizing titer profiles in convalescent plasma samples to determine the optimal donation window for immunotherapy.

Relationship between Anti-Spike Protein Antibody Titers and SARS-CoV-2 In Vitro Virus Neutralization in Convalescent Plasma

This study finds a strong correlation between anti-RBD and anti-ECD IgG titers and in vitro virus neutralization titers in convalescent plasma, suggesting these titers can serve as surrogates for neutralizing activity.