A Second Generation Leishmanization Vaccine with a Markerless Attenuated Leishmania major Strain using CRISPR gene editing
W. W. Zhang, S. Karmakar, S. Gannavaram, R. Dey, P. Lypaczewski, N. Ismail, A. Siddiqui, V. Simonyan, F. Oliveira, I. V. Coutinho-Abreu, T. DeSouza-Vieira, C. Meneses, J. Oristian, T. D. Serfim, A. Musa, , H. L. Nakhasi
This paper describes a CRISPR-edited Leishmania major strain for a second-generation leishmanization vaccine that is marker-free and safe, showing protection in mice comparable to traditional leishmanization.
bioRxiv · May 4, 2020Microbiology