Author

H. L. Nakhasi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Assay:proteomics· 1

Frequent Co-Authors

G. Matlashewski· 3 shared N. Ismail· 3 shared R. DEY· 3 shared S. Gannavaram· 3 shared S. Hamano· 3 shared S. Karmakar· 3 shared A. Satoskar· 2 shared C. Meneses· 2 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

G. Matlashewski

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Author profile →

3 papers

Recent·Most cited

Skin resident memory cells generated by the L. major centrin gene deleted parasites mediate protective immune response analogous to leishmanization

N. Ismail, S. Karmakar, P. Bhattacharya, T. Sepahpour, K. Takeda, S. Hamano, G. Matlashewski, A. R. Satoskar, S. Gannavaram, R. DEY, H. L. Nakhasi

This study shows that a genetically modified Leishmania vaccine generates skin-resident memory T cells that provide protection similar to leishmanization.

bioRxiv · Dec 17, 2021 · PreprintImmunology

Preclinical validation of a second generation leishmanization vaccine against vector transmitted fatal visceral leishmaniasis

H. L. Nakhasi, R. DEY, S. Gannavaram, S. Karmakar, P. Bhattacharya, N. Ismail, A. Satoskar, G. Volpedo, L. F. Oliveira, J. Oristian, C. Meneses, J. G. Valenzuela, S. Kamhawi, W. W. Zhang, G. Matlashewski, , K. Pandey

This study evaluates the protective efficacy of a CRISPR-edited Leishmania major strain against visceral leishmaniasis in hamsters and shows it induces a pro-inflammatory immune response and prevents disease.

bioRxiv · Nov 18, 2020Immunology

A Second Generation Leishmanization Vaccine with a Markerless Attenuated Leishmania major Strain using CRISPR gene editing

W. W. Zhang, S. Karmakar, S. Gannavaram, R. Dey, P. Lypaczewski, N. Ismail, A. Siddiqui, V. Simonyan, F. Oliveira, I. V. Coutinho-Abreu, T. DeSouza-Vieira, C. Meneses, J. Oristian, T. D. Serfim, A. Musa, , H. L. Nakhasi

This paper describes a CRISPR-edited Leishmania major strain for a second-generation leishmanization vaccine that is marker-free and safe, showing protection in mice comparable to traditional leishmanization.

bioRxiv · May 4, 2020Microbiology