Author

V. van Unen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

C. Kuo· 2 shared A. A. Salahudeen· 1 shared A. Batish· 1 shared A. Califano· 1 shared A. Christophersen· 1 shared A. J. M. Santos· 1 shared A. M. Trumbull· 1 shared A. McCormick· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersPhysiology

C. Kuo

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Key role of down-regulated in adenoma (SLC26A3) chloride/bicarbonate exchanger in linaclotide-stimulated intestinal bicarbonate secretion upon loss of CFTR function

J. B. Sarthi, A. M. Trumbull, S. M. Abazari, V. van Unen, J. E. Chan, Y. Jiang, J. Gammons, M. O. Andrerson, O. Cil, C. Kuo, Z. M. Sellers

This study shows linaclotide stimulates bicarbonate secretion in CFTR-deficient tissues by enhancing DRA expression, suggesting DRA as a therapeutic target for CF-related intestinal dysfunction.

bioRxiv · May 5, 2023 · PreprintPhysiology

Therapeutic modulation of the blood-brain barrier and ischemic stroke by a bioengineered FZD4-selective WNT surrogate

J. Ding, S.-J. Lee, L. Vlahos, K. Yuki, C. Rada, V. van Unen, M. Vuppalapaty, H. Chen, A. Sura, A. McCormick, M. Tomaske, S. Alwahabi, H. Nguyen, W. Nowatzke, L. Kim, , C. Kuo

This study develops a bioengineered FZD4-selective WNT surrogate that improves BBB function and reduces ischemic stroke damage in mice.

bioRxiv · Oct 13, 2022 · PreprintPhysiology

Human KIR+CD8+ T cells target pathogenic T cells in Celiac disease and are active in autoimmune diseases and COVID-19

J. Li, M. E. Zaslavsky, Y. Su, M. Sikora, V. van Unen, A. Christophersen, S.-H. Chiou, L. Chen, J. Li, X. Ji, J. Wilhelmy, A. McSween, B. A. Palanski, V. Mallajosyula, G. Dhondalay, , M. Davis

The paper identifies KIR+CD8+ T cells as regulatory cells in humans that suppress pathogenic CD4+ T cells in autoimmune and infectious diseases.

bioRxiv · Dec 23, 2021 · PreprintImmunology

Progenitor identification and SARS-CoV-2 infection in long-term human distal lung organoid cultures

A. A. Salahudeen, S. S. Choi, A. Rustagi, J. Zhu, S. M. de la O, R. A. Flynn, M. Margalef-Catala, A. J. M. Santos, J. Ju, A. Batish, V. van Unen, T. Usui, G. X. Y. Zheng, C. E. Edwards, L. E. Wagar, , C. J. Kuo

This paper develops a feeder-free organoid culture system for human distal lung progenitors and demonstrates SARS-CoV-2 infection of club cells in a novel in vitro model.

bioRxiv · Jul 27, 2020 · PreprintCell Biology