Author

A. A. Salahudeen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:drug response / drug discovery· 3 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Approach:genetic perturbation / CRISPR· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:CRISPR screen· 1

Frequent Co-Authors

C. J. Kuo· 4 shared A. Batish· 3 shared T. J. Desai· 3 shared C. M. Lee· 2 shared D. J. Hart· 2 shared D. T. Bravo· 2 shared G. Bao· 2 shared J. J. Wine· 2 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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4 shared papersBioengineering

C. J. Kuo

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Pan-cancer organoid validation of tumor outlier chromosomal amplification events

A. A. Salahudeen, K. Yuki, J. Seoane, A. T. Mah, A. R. Smith, K. Kolahi, S. M. De la O, D. J. Hart, J. Ding, Z. Ma, S. A. Barkal, N. D. Shukla, H. C. Zhang, M. A. Cantrell, A. Batish, , C. J. Kuo

The paper validates oncogenic chromosomal amplification events across multiple cancers using organoid models and functional assays.

bioRxiv · Oct 5, 2021 · PreprintCancer Biology

Targeted replacement of full-length CFTR in human airway stem cells by CRISPR/Cas9 for pan-mutation correction in the endogenous locus

S. Vaidyanathan, R. Baik, L. Chen, D. T. Bravo, C. J. Suarez, S. M. Abazari, A. A. Salahudeen, A. M. Dudek, C. A. Teran, T. H. Davis, C. M. Lee, G. Bao, S. H. Randell, S. E. Artandi, J. J. Wine, , M. Porteus

This study corrects multiple CFTR mutations in human airway stem cells using CRISPR/Cas9 and AAV vectors, achieving functional restoration in differentiated epithelial cells.

bioRxiv · Feb 26, 2021Bioengineering

Progenitor identification and SARS-CoV-2 infection in long-term human distal lung organoid cultures

A. A. Salahudeen, S. S. Choi, A. Rustagi, J. Zhu, S. M. de la O, R. A. Flynn, M. Margalef-Catala, A. J. M. Santos, J. Ju, A. Batish, V. van Unen, T. Usui, G. X. Y. Zheng, C. E. Edwards, L. E. Wagar, , C. J. Kuo

This paper develops a feeder-free organoid culture system for human distal lung progenitors and demonstrates SARS-CoV-2 infection of club cells in a novel in vitro model.

bioRxiv · Jul 27, 2020 · PreprintCell Biology

Highly Efficient Repair of the ΔF508 Mutation in Airway Stem Cells of Cystic Fibrosis Patients with Functional Rescue of the Differentiated Epithelia

S. Vaidyanathan, A. A. Salahudeen, Z. M. Sellers, D. T. Bravo, S. S. Choi, A. Batish, W. Le, S. De La O, M. P. Kaushik, N. Galper, C. M. Lee, G. Bao, E. H. Chang, J. J. Wine, C. E. Milla, , M. H. Porteus

This paper corrects the ΔF508 mutation in CF patient airway stem cells using CRISPR-Cas9 and AAV6, achieving high correction rates and functional rescue in differentiated epithelia.

bioRxiv · Feb 26, 2019 · PreprintBioengineering