Author

V. Y. Arshavsky

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 4 Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:cell type annotation· 4 Research Focus:development & morphogenesis· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Assay:electronic health records· 2 Organism:fungi (other)· 1

Frequent Co-Authors

N. P. Skiba· 4 shared T. R. Lewis· 4 shared C. M. Castillo· 3 shared W. J. Spencer· 2 shared Y. Hao· 2 shared A. K. Menon· 1 shared A. M. Payne· 1 shared A. N. Pillai· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersCell Biology

N. P. Skiba

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

ROM1 is redundant to PRPH2 as a molecular building block of photoreceptor disc rims

T. R. Lewis, M. S. Makia, C. M. Castillo, Y. Hao, M. R. Al-Ubaidi, N. P. Skiba, S. M. Conley, V. Y. Arshavsky, M. I. Naash

This study shows that ROM1 can be replaced by increased PRPH2 levels to restore normal photoreceptor disc structure in knockout mice.

bioRxiv · Jul 2, 2023Cell Biology

Photoreceptor disc incisures form as an adaptive mechanism ensuring the completion of disc enclosure

T. R. Lewis, S. Phan, C. M. Castillo, K.-Y. Kim, K. Coppenrath, W. Thomas, Y. Hao, N. P. Skiba, M. E. Horb, M. H. Ellisman, V. Y. Arshavsky

This study shows incisures in photoreceptor discs form after complete enclosure and are regulated by the ratio of peripherin-2 to rhodopsin.

bioRxiv · Apr 6, 2023Cell Biology

Absolute quantification of photoreceptor outer segment proteins

N. P. Skiba, T. R. Lewis, W. J. Spencer, C. M. Castillo, A. Shevchenko, V. Y. Arshavsky

This study uses quantitative mass spectrometry to determine the absolute protein abundances in mouse rod outer segments, resolving discrepancies and showing high precision in molar ratios.

bioRxiv · Jan 19, 2023Biochemistry

The WAVE complex drives the morphogenesis of the photoreceptor outer segment cilium

W. J. Spencer, N. F. Schneider, N. P. Skiba, V. Y. Arshavsky

The paper identifies the WAVE complex as the nucleation promoting factor for actin polymerization during photoreceptor outer segment disc morphogenesis and shows its necessity for proper outer segment formation.

bioRxiv · Nov 21, 2022 · PreprintCell Biology

Unusual mode of dimerization of retinitis pigmentosa-associated F220C rhodopsin

G. Khelashvili, A. N. Pillai, J. Lee, K. Pandey, A. M. Payne, Z. Siegel, M. A. Cuendet, T. R. Lewis, V. Y. Arshavsky, J. Broichhagen, J. Levitz, A. K. Menon

The paper investigates the dimerization behavior of F220C rhodopsin mutant and wild-type opsin in vitro and in the plasma membrane, finding that the mutant forms a unique dimer with distinct conformational features.

bioRxiv · Dec 28, 2020Biophysics

The GARP Domain of the Rod CNG Channel's β1-subunit Contains Distinct Sites for Outer Segment Targeting and Connecting to the Photoreceptor Disc Rim

J. N. Pearring, J. R. Willer, J. Y. Martinez-Marquez, E. C. Lieu, R. Y. Salinas, V. Y. Arshavsky

This study identifies specific regions in the CNG channel's β1-subunit that mediate outer segment targeting and disc rim connection, revealing functional specializations in its structure.

bioRxiv · Oct 1, 2020Cell Biology