M. H. Ellisman

Fe-TAMLs as a new class of small molecule peroxidase probes for correlated light and electron microscopy

The paper introduces Fe-TAML, a small molecule peroxidase probe for correlated light and electron microscopy, demonstrating its use in imaging DNA, tagged proteins, and endogenous proteins.

Caloric restriction promotes beta cell longevity and delays aging and senescence by enhancing cell identity and homeostasis mechanisms.

This study shows caloric restriction enhances beta cell identity and homeostasis, delays aging and senescence, and improves mitochondrial function in pancreatic beta cells.

Proximal Molecular Probe Transfer (PROMPT), a new approach for identifying sites of protein/nucleic acid interaction in cells by correlated light and electron microscopy

The paper introduces PROMPT, a method to identify protein/nucleic acid interaction sites using correlated light and electron microscopy, demonstrating its application with histone H2B and Fibrillarin.

TorsinA is essential for the timing and localization of neuronal nuclear pore complex biogenesis

The paper identifies torsinA's role in regulating NPC spatial organization during neuronal maturation without affecting NPC density.

Photoreceptor disc incisures form as an adaptive mechanism ensuring the completion of disc enclosure

This study shows incisures in photoreceptor discs form after complete enclosure and are regulated by the ratio of peripherin-2 to rhodopsin.

Spatial and functional arrangement of Ebola virus polymerase inside phase-separated viral factories

This study investigates the spatial and functional organization of Ebola virus polymerase within viral factories, revealing distinct structural forms and their roles in viral replication.

SARS-CoV-2 spike protein induces abnormal inflammatory blood clots neutralized by fibrin immunotherapy

This study shows SARS-CoV-2 Spike protein causes abnormal blood clots and thromboinflammation, which are neutralized by a fibrin-targeting antibody.

Unconventional tonicity-regulated nuclear trafficking of NFAT5 mediated by KPNB1, XPOT and RUVBL2

This study identifies KPNB1 and RUVBL2 as key regulators of NFAT5's unconventional tonicity-dependent nuclear trafficking.

Mitochondrial morphology provides a mechanism for energy buffering at synapses

The paper presents an agent-based model of mitochondrial morphology at synapses, showing that internal structure influences energy buffering and cellular robustness.

Split-miniSOG for detecting and localizing intracellular protein-protein interactions: application to correlated light and electron microscopy

The paper introduces Split-miniSOG, a PCA method to detect and localize PPIs using correlated light and electron microscopy.

CDeep3M - Plug-and-Play cloud based deep learning for image segmentation of light, electron and X-ray microscopy

CDeep3M provides a cloud-based deep learning tool for image segmentation across light, electron, and X-ray microscopy, simplifying access and computation for researchers.

High-quality ultrastructural preservation using cryofixation for 3D electron microscopy of genetically labeled tissues

This paper develops a method to enable genetically labeled cryofixed samples to be analyzed with SBEM and 3D CLEM, overcoming previous technical limitations.