Author

T. R. Lewis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 1 Biophysics· 1 Ecology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:mouse· 4 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 1 Research Focus:ecology & biodiversity· 1 Assay:electronic health records· 1

Frequent Co-Authors

V. Y. Arshavsky· 4 shared C. M. Castillo· 3 shared N. P. Skiba· 3 shared Y. Hao· 2 shared A. K. Menon· 1 shared A. M. Payne· 1 shared A. N. Pillai· 1 shared A. Shevchenko· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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4 shared papersCell Biology

V. Y. Arshavsky

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

ROM1 is redundant to PRPH2 as a molecular building block of photoreceptor disc rims

T. R. Lewis, M. S. Makia, C. M. Castillo, Y. Hao, M. R. Al-Ubaidi, N. P. Skiba, S. M. Conley, V. Y. Arshavsky, M. I. Naash

This study shows that ROM1 can be replaced by increased PRPH2 levels to restore normal photoreceptor disc structure in knockout mice.

bioRxiv · Jul 2, 2023Cell Biology

Photoreceptor disc incisures form as an adaptive mechanism ensuring the completion of disc enclosure

T. R. Lewis, S. Phan, C. M. Castillo, K.-Y. Kim, K. Coppenrath, W. Thomas, Y. Hao, N. P. Skiba, M. E. Horb, M. H. Ellisman, V. Y. Arshavsky

This study shows incisures in photoreceptor discs form after complete enclosure and are regulated by the ratio of peripherin-2 to rhodopsin.

bioRxiv · Apr 6, 2023Cell Biology

Absolute quantification of photoreceptor outer segment proteins

N. P. Skiba, T. R. Lewis, W. J. Spencer, C. M. Castillo, A. Shevchenko, V. Y. Arshavsky

This study uses quantitative mass spectrometry to determine the absolute protein abundances in mouse rod outer segments, resolving discrepancies and showing high precision in molar ratios.

bioRxiv · Jan 19, 2023Biochemistry

Unusual mode of dimerization of retinitis pigmentosa-associated F220C rhodopsin

G. Khelashvili, A. N. Pillai, J. Lee, K. Pandey, A. M. Payne, Z. Siegel, M. A. Cuendet, T. R. Lewis, V. Y. Arshavsky, J. Broichhagen, J. Levitz, A. K. Menon

The paper investigates the dimerization behavior of F220C rhodopsin mutant and wild-type opsin in vitro and in the plasma membrane, finding that the mutant forms a unique dimer with distinct conformational features.

bioRxiv · Dec 28, 2020Biophysics

Assessing bird collisions in the United Kingdom: Modelling frequency of bird-strike from road and rail mortality using a Bayesian hierarchical approach

S. Freire, L. Read, T. R. Lewis

The paper models bird-strike frequency from road and rail mortality in the UK using Bayesian hierarchical models, finding Barn owls most affected and juveniles/males more susceptible.

bioRxiv · Dec 4, 2020 · PreprintEcology

Kif17 phosphorylation regulates its ciliary localization and photoreceptor outer segment turnover

T. R. Lewis, S. R. Kundinger, B. A. Link, C. Insinna, J. C. Besharse

This study shows that phosphorylation of KIF17 enhances its ciliary localization and promotes photoreceptor outer segment turnover through disc shedding.

bioRxiv · Jun 20, 2018Cell Biology