Mutational and functional heterogeneity of homology-directed repair deficiency and clinical implications
Salome Jingchen Zhao, Ching Chiek Koh, Rachel Brough, Dragomir B. Krastev, Veenu Tripathi, Feifei Song, Sheyne S. A. Choi, Daniella Black, Soraya Boushaki, Cherif Badja, Rebecca A. Dagg, Giuseppe Rinaldi, Ping Jing Toong, Andrea Degasperi, Rohit Prakash, , Serena Nik‐Zainal
The paper shows HRd is a continuum with functional and mutational heterogeneity, highlighting the need for refined molecular classification for precision interventions.
bioRxiv · May 29, 2026 · PreprintGenomics