ACSS2 Regulates HIF-2α Degradation through the E3-Ubiquitin Ligase MUL1 in Clear Cell Renal Cell Carcinoma
Z. A. Bacigalupa, W. A. Brown, E. S. Krystofiak, M. M. Wolf, R. A. Hongo, M. Landis, E. K. Amason, K. E. Beckermann, J. C. Rathmell, W. K. Rathmell
This study shows ACSS2 promotes HIF-2 stability by preventing its interaction with MUL1, and inhibiting ACSS2 reduces HIF-2 levels and suppresses ccRCC growth.
bioRxiv · Apr 21, 2022 · PreprintCancer Biology