Author

C. M. Lee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Immunology· 1 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Approach:genetic perturbation / CRISPR· 2 Organism:rat· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1

Frequent Co-Authors

A. A. Salahudeen· 2 shared C. J. Kuo· 2 shared D. T. Bravo· 2 shared G. Bao· 2 shared J. J. Wine· 2 shared J. V. Nayak· 2 shared S. Vaidyanathan· 2 shared T. J. Desai· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBioengineering

A. A. Salahudeen

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Rat hepatitis E virus (HEV) cross-species infection and transmission in pigs

K. K. Yadav, P. A. Boley, C. M. Lee, S. Khatiwada, K. Jung, T. Laocharoensuk, J. Hofstetter, R. Wood, J. Hanson, S. P. Kenney

This study investigates whether pigs can transmit rat HEV to other pigs, finding that an infectious clone of rat HEV replicates in vitro and infects pigs, which then transmit the virus to cohoused animals.

bioRxiv · Jul 6, 2023Microbiology

Mechanisms underlying the efficacy of a rodent model of vertical sleeve gastrectomy - a focus on energy expenditure

A. Stefanidis, C. M. Lee, E. Greaves, M. Montgomery, M. Arnold, S. Newn, A. Budin, C. J. Foldi, P. R. Burton, W. A. Brown, T. A. Lutz, M. J. Watt, B. J. Oldfield

This study investigates the role of brown adipose tissue thermogenesis in the efficacy of vertical sleeve gastrectomy in rodents, showing its impact on weight loss and glucose regulation.

bioRxiv · Mar 7, 2022Physiology

Host Chitinase 3-like-1 is a Universal Therapeutic Target for SARS-CoV-2 Viral Variants in COVID 19

S. Kamle, B. Ma, C. M. Lee, G. Schor, Y. Zhou, C. G. Lee, J. A. Elias

This study shows that targeting CHI3L1 inhibits SARS-CoV-2 variants' infection of epithelial cells, suggesting it as a universal therapeutic target.

bioRxiv · Jan 21, 2022Immunology

Targeted replacement of full-length CFTR in human airway stem cells by CRISPR/Cas9 for pan-mutation correction in the endogenous locus

S. Vaidyanathan, R. Baik, L. Chen, D. T. Bravo, C. J. Suarez, S. M. Abazari, A. A. Salahudeen, A. M. Dudek, C. A. Teran, T. H. Davis, C. M. Lee, G. Bao, S. H. Randell, S. E. Artandi, J. J. Wine, , M. Porteus

This study corrects multiple CFTR mutations in human airway stem cells using CRISPR/Cas9 and AAV vectors, achieving functional restoration in differentiated epithelial cells.

bioRxiv · Feb 26, 2021Bioengineering

Highly Efficient Repair of the ΔF508 Mutation in Airway Stem Cells of Cystic Fibrosis Patients with Functional Rescue of the Differentiated Epithelia

S. Vaidyanathan, A. A. Salahudeen, Z. M. Sellers, D. T. Bravo, S. S. Choi, A. Batish, W. Le, S. De La O, M. P. Kaushik, N. Galper, C. M. Lee, G. Bao, E. H. Chang, J. J. Wine, C. E. Milla, , M. H. Porteus

This paper corrects the ΔF508 mutation in CF patient airway stem cells using CRISPR-Cas9 and AAV6, achieving high correction rates and functional rescue in differentiated epithelia.

bioRxiv · Feb 26, 2019 · PreprintBioengineering