Author

K. E. Beckermann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:metabolism & bioenergetics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:imaging· 1 Assay:metabolomics· 1

Frequent Co-Authors

J. C. Rathmell· 4 shared W. K. Rathmell· 4 shared B. I. Reinfeld· 3 shared M. M. Wolf· 3 shared R. A. Hongo· 3 shared A. Ali· 2 shared A. Muir· 2 shared C. A. Lewis· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

J. C. Rathmell

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Author profile →

4 papers

Recent·Most cited

Metabolite profiling of human renal cell carcinoma reveals tissue-origin dominance in nutrient availability

K. L. Abbott, A. Ali, B. I. Reinfeld, A. A. I. Deik, S. Subudhi, M. D. Landis, R. A. Hongo, K. L. Young, T. Kunchok, C. S. Nabel, K. D. Crowder, J. R. Kent, M. L. L. Madariaga, R. K. Jain, K. E. Beckermann, , M. G. Vander Heiden

This study profiles metabolites in renal cell carcinoma tissue and fluid to show that nutrient availability is more influenced by tissue-specific factors than tumor-driven changes.

bioRxiv · Dec 24, 2023Cancer Biology

PD-1 is induced on tumor-associated macrophages in obesity to directly restrain anti-tumor immunity

J. E. Bader, M. M. Wolf, M. Z. Madden, B. I. Reinfeld, E. N. Arner, E. S. Hathaway, K. K. Steiner, G. A. Needle, M. D. Landis, M. A. Cottam, X. Ye, A. Christofides, V. A. Boussiotis, S. M. Haake, K. E. Beckermann, , J. C. Rathmell

This study shows obesity induces PD-1 on tumor-associated macrophages, which suppresses anti-tumor immunity by altering metabolic and functional properties of these cells.

bioRxiv · Nov 12, 2022 · PreprintImmunology

ACSS2 Regulates HIF-2α Degradation through the E3-Ubiquitin Ligase MUL1 in Clear Cell Renal Cell Carcinoma

Z. A. Bacigalupa, W. A. Brown, E. S. Krystofiak, M. M. Wolf, R. A. Hongo, M. Landis, E. K. Amason, K. E. Beckermann, J. C. Rathmell, W. K. Rathmell

This study shows ACSS2 promotes HIF-2 stability by preventing its interaction with MUL1, and inhibiting ACSS2 reduces HIF-2 levels and suppresses ccRCC growth.

bioRxiv · Apr 21, 2022 · PreprintCancer Biology

Cell Programmed Nutrient Partitioning in the Tumor Microenvironment

B. I. Reinfeld, M. Z. Madden, M. M. Wolf, A. Chytil, J. E. Bader, A. R. Patterson, A. S. Cohen, A. Ali, B. T. Do, C. A. Lewis, A. Muir, R. A. Hongo, K. L. Young, R. E. Brown, V. M. Todd, , W. K. Rathmell

The paper measures nutrient uptake in the tumor microenvironment using PET tracers and finds cancer cells prefer glutamine while myeloid cells consume most glucose.

bioRxiv · Aug 10, 2020 · PreprintCancer Biology