Author

W. A. Koltun

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

G. S. Yochum· 2 shared C. Delierneux· 1 shared D. L. Gill· 1 shared I. Sekler· 1 shared M. Gueguinou· 1 shared M. T. Johnson· 1 shared M. Trebak· 1 shared N. Hempel· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCell Biology

G. S. Yochum

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2 papers

Recent·Most cited

Mucin MUC5B levels are reduced in the colonic epithelia of ulcerative colitis patients

W. Ding, W. A. Koltun, G. S. Yochum

This study shows that MUC5B levels are reduced in ulcerative colitis colonic tissues and organoids, and IL-1β fails to induce MUC5B expression in UC-derived organoids.

bioRxiv · Feb 21, 2024 · PreprintCell Biology

Colorectal adenocarcinomas downregulate the mitochondrial Na+/Ca2+ exchanger NCLX to drive metastatic spread

T. Pathak, M. Gueguinou, V. Walter, C. Delierneux, M. T. Johnson, X. Zhang, P. Xin, R. E. Yoast, S. M. Emrich, G. S. Yochum, I. Sekler, W. A. Koltun, D. L. Gill, N. Hempel, M. Trebak

This study shows that reduced NCLX expression in colorectal tumors leads to mtCa2+ overload, promoting metastasis and chemoresistance through mtROS/HIF1 signaling.

bioRxiv · May 7, 2020 · PreprintCancer Biology